Thyroid Hormone Export Regulates Cellular Hormone Content and Response

Cellular Action of Thyroid Hormone

• Rohit Sinha, M.D. Research Fellow Laboratory of Hormonal Regulation Cardiovascular and Metabolic Disease Program Duke-NUS Graduate Medical School 8 College Road, Level 8 Singapore 169857 • Paul M. Yen, M.D. Associate Professor Laboratory of Hormonal Regulation, Cardiovascular and Metabolic Disease Program Duke-NUS Graduate Medical School, 8 College Road, Level 8, Singapore 169857 Molecular Re...

Thyroid hormone regulates the hypotriglyceridemic gene APOA5.

The apolipoprotein AV gene (APOA5) is a key determinant of plasma triglyceride levels, a major risk factor for coronary artery disease and a biomarker for the metabolic syndrome. Since thyroid hormones influence very low density lipoprotein triglyceride metabolism and clinical studies have demonstrated an inverse correlation between thyroid status and plasma triglyceride levels, we examined whe...

Thyroid Hormone Transport into Cellular Tissue

New research is demonstrating that thyroid hormone transport across cellular membranes plays an important role in intracellular triiodothyronine (T3) levels of peripheral and pituitary tissues and is proving to have considerable clinical significance. Reduced T4 and T3 transport into the cells in peripheral tissues is seen with a wide range of common conditions, including insulin resistance, di...

Thyroid Stimulating Hormone Thyroid Stimulating Hormone

Thyroid hormone export from cells: contribution of P-glycoprotein.

Verapamil inhibits tri-iodothyronine (T3) efflux from several cell types, suggesting the involvement of multidrug resistance-associated (MDR) proteins in T3 transport. The direct involvement of P-glycoprotein (P-gp) has not, however, been investigated. We compared the transport of 125I-T3 in MDCKII cells that had been transfected with mdr1 cDNA (MDCKII-MDR) versus wild-type MDCKII cells (MDCKII...